Haloperidol

Class : Antipsychotics, Antivertigo Drugs
See available brands of haloperidol

Indication
Listed in Dosage.
Dosage
PO Psychoses 0.5-5 mg 2-3 times/day, up to 100 mg/day in severe cases. Maintenance: 3-10 mg/day. Severe tics; Tourette’s syndrome Initial: 0.5-1.5 mg 3 times/day, up to 10 mg/day in Tourette’s syndrome. Adjunct in severe anxiety or behavioral disturbances 0.5 mg twice daily. Restlessness and confusion 1-3 mg 8 hrly. Intractable hiccup 1.5 mg 3 times/day. IM Acute psychosis 2-10 mg hrly or 4-8 hrly until symptoms are controlled. Max: 18 mg/day. Nausea and vomiting 0.5-2 mg/day. SC Restlessness and confusion 5-15 mg over 24 hr.
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Administration
May be taken with or without food. (May be taken w/ meals to minimise GI irritation.)

Overdosage
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Contraindications
Severe toxic CNS depression; preexisting coma; Parkinson’s disease; lactation.

Special Precautions
Parkinsonism; epilepsy, allergy, angle-closure glaucoma, benign prostatic hyperplasia; severe cardiac or hepatic disease; extremes in temp (hot and cold weather); presence of acute infections or leucopenia; hyperthyroidism; pregnancy, elderly, children. Patients receiving anticoagulants. Discontinue upon signs of neurological toxicity in patients taking haloperidol and lithium.

Adverse Drug Reactions
Tardive dyskinesia; extrapyramidal reactions. Anxiety, drowsiness, depression, anorexia, transient tachycardia, postural hypotension, leukopenia; anticholinergic side effects.
Potentially Fatal: Neuroleptic malignant syndrome.

Drug Interactions
Carbamazepine and rifampicin reduce plasma concentrations. Symptoms of CNS depression may be enhanced by CNS depressants e.g. alcohol, hypnotics, general anaesthetics, anxiolytics and opioids. May reduce antihypertensive action of guanethidine. May increase risk of arrhythmia when used with drugs that prolong QT interval or diuretics that can cause electrolyte imbalance. May increase plasma levels of haloperidol when used with clozapine or chlorpromazine.
Potentially Fatal: Increases lithium blood levels and may predispose to neuroleptic malignant syndrome.
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Pregnancy Category
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Storage
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Mechanism of Action For details of the mechanism of action, pharmacology and pharmacokinetics and toxicology

ATC Classification
N05AD01 - Haloperidol; Belongs to the class of butyrophenone derivatives antipsychotics. Used in the management of psychosis.

Brands : Haldol amp Haldol tab Phil Pharmawealth/Atlantic Haloperidol amp Seredol Deca amp Serenace amp Serenace tab